The Parthenon in Athens (432 BC)
Greece was followed by Rome, which left its mark on law, politics, language, engineering, architecture, government and many more key aspects in western civilisation. Expanding from their base in Italy beginning in the 3rd century BC, the Romans gradually expanded to eventually rule the entire Mediterranean basin and western Europe by the turn of the millennium. The Roman Republic ended in 27 BC, when Augustus proclaimed the Roman Empire. The two centuries that followed are known as the pax romana, a period of unprecedented peace, prosperity, and political stability in most of Europe.
The empire continued to expand under emperors such as Hadrian, Antoninus Pius, and Marcus Aurelius, who all spent time on the Empire's northern border fighting Germanic, Pictish and Scottish tribes. The Empire began to decline in the 3rd century, particularly in the west. Christianity was legalised by Constantine I in 313 AD after three centuries of imperial persecution. Constantine also permanently moved the capital of the empire from Rome to the city of Byzantium, which was renamed Constantinople in his honour (modern-day Istanbul) in 330 AD. Christianity became the sole official religion of the empire in 380 AD, and in 391-392 AD, the emperor Theodosius outlawed pagan religions. This is sometimes considered to mark the end of antiquity; alternatively antiquity is considered to end with the fall of the Western Roman Empire in 476 AD; the closure of the pagan Platonic Academy of Athens in 529 AD; or the rise of Islam in the early 7th century AD.
(source)